Let's depart from philosophical discussions, and talk specific ideas.
Etsy.com started off quietly, referred to as the eBay of handicrafts, but is now much more than a boutique. People earn good revenue through side businesses selling their handmade goods over the store. Being more focused than eBay has been their strength. (example: our shop)
Think Etsy is too large? Try Wedzu, a handicraft sales-enabling site, like Etsy, that focuses only on wedding-related gear.
This is something YOU can do from your tiny town, out there "on the edge of the prairie."